A misdiagnosed myasthenia gravis with anti-muscle-specific tyrosine kinase antibodies with possible childhood onset
نویسندگان
چکیده
منابع مشابه
Myasthenia gravis patients with anti-MuSK antibodies.
In myasthenia gravis (MG) patients without detectable anti-acetylcholine receptor (anti-AChR) antibody, referred to as seronegative myasthenia gravis patients, there is a variable proportion of patients with antibodies against the muscle-specific kinase (MuSK). MuSK antibodies were found in 8 (29.6%) of our 27 patients with generalized MG without anti-AChR antibodies. All these patients were fe...
متن کاملKey words: seronegative myasthenia gravis, muscle atrophy, muscle-specific receptor tyrosine kinase (MuSK) antibody, tongue atrophy Myasthenia gravis
Myasthenia gravis (MG) is an autoimmune disorder with easy fatigability of the muscles based on a neuromuscular transmission defect. Most myasthenic patients have antiacetylcholine receptor antibodies which attach to the acetycholine receptor of the postsynaptic membrane of the skeletal muscles and decrease the amplitude of miniature endplate potentials (mepp) and endplate potentials (epp) caus...
متن کاملThymectomy in Patients with Myasthenia Gravis
A case of myasthenia gravis in a 15 years old girl is pre·sented. The disease was present for 5 years before thymectomy was performed. Indications for thymectomy, preoperative preparation, anesthetic and surgical management is -discussed.
متن کاملMuscle-Specific Receptor Tyrosine Kinase Antibody Positive Myasthenia Gravis Current Status
Muscle-specific tyrosine-kinase-antibody-positive myasthenia gravis (MuSK-MG) has emerged as a distinct entity since 2001. This disease has been reported worldwide, but with varying rates among patients with generalized acetylcholine-receptor-antibody-negative MG. MuSK-MG was detected in approximately 37% of generalized acetylcholine receptor antibody-negative MG. MuSK-MG patients were predomin...
متن کاملTissue-specific antibodies in myasthenia gravis.
Myasthenia gravis (MG) is a disorder of the neuromuscular junction characterised by weakness which increases on effort and is improved by rest and anticholinesterase treatment. Thymic abnormality with increased numbers of germinal centres is common, thymoma occurs in about 15% of cases, and thymectomy is often beneficial in thosewithoutatumour. The condition is commoner in women and typically b...
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ژورنال
عنوان ژورنال: Military Medical and Pharmaceutical Journal of Serbia
سال: 2015
ISSN: 0042-8450,2406-0720
DOI: 10.2298/vsp131111039n